Efficacy of tofacitinib in patients with rheumatoid arthritis stratified by background methotrexate dose group
نویسندگان
چکیده
منابع مشابه
Efficacy of tofacitinib monotherapy in methotrexate-naive patients with early or established rheumatoid arthritis
INTRODUCTION Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Tofacitinib monotherapy was previously shown to inhibit structural damage, reduce clinical signs and symptoms of RA, and improve physical functioning over 24 months in methotrexate (MTX)-naive adult patients with RA. In this post hoc analysis, we compared efficacy and safety of tofacitinib...
متن کاملLiver Toxicity in Rheumatoid Arthritis Patients Treated With Methotrexate
Background:Methotrexate (MTX) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (RA) which can be associated with toxic effects on different organs. This study was designed to investigate the hepatotoxic effects in RA patients treated with MTX. Methods: In this cross-sectional observational study, RA patients who received standard d...
متن کاملmethotrexate hepatotoxicity in patients with rheumatoid arthritis
background increases in aminotransferases (transaminitis) are potential major adverse reactions seen with long-term use of methotrexate (mtx). the aim of this study, therefore was to evaluate the incidence of mtx induced hepatotoxicity and its risk factors among rheumatoid arthritis (ra) patients. methods this retrospective study described 286 patients with ra who received ≤ 7.5 mg mtx weekly...
متن کاملFactors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis.
OBJECTIVE To study factors associated with toxicity, final dose, and efficacy of methotrexate (MTX) in patients with rheumatoid arthritis (RA). METHODS Data were used from a randomised clinical 48 week trial on 411 patients with RA all treated with MTX, comparing folates and placebo. Logistic regression was used to study the relation between baseline variables and various dependent factors, i...
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ژورنال
عنوان ژورنال: Clinical Rheumatology
سال: 2016
ISSN: 0770-3198,1434-9949
DOI: 10.1007/s10067-016-3436-1